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Research Affiliates

Head shot of Sarah Schlesinger
Sarah J. Schlesinger, M.D.
Senior Attending Physician
Associate Professor of Clinical Investigation
Laboratory of Molecular Immunology
Sarah.Schlesinger@rockefeller.edu

Schlesinger chairs The Rockefeller University Institutional Review Board and the research education and training committee, which is part of the Center for Clinical and Translational Science. She also serves as director of the Clinical Scholars Program and the Certificate in Clinical and Translational Sciences Program.

Previously, Schlesinger was involved in clinical trials of 11 HIV vaccines and vaccine adjuvants. She is now conducting the first HIV vaccine trial based on dendritic cells, which were discovered at Rockefeller in 1973 by Ralph M. Steinman and his mentor, Zanvil A. Cohn.

In the steady state, dendritic cells capture antigens and travel to immune or lymphoid tissues, where they present the antigens to T cells, stimulating a robust immune response. But dendritic cells also play a seemingly opposite role, immune tolerance, silencing dangerous immune cells and preventing them from attacking the body’s own tissues. Working with Steinman, Schlesinger used dendritic cells to study and design treatments that can either enhance the immune system or silence its functions in an antigen- or disease-specific manner.